Anorectal Malformation

Both the upper and lower esophageal pouch make an abnormal connection with the trachea in two separate, isolated places. Pallister-Hall syndrome is a pleiotropic autosomal dominant disorder comprising hypothalamic hamartoma, pituitary dysfunction, central polydactyly, and visceral malformations Biesecker et al. More severe malformations may occur in some cases. Most cases occur randomly, for no apparent reason sporadic. New insights into genotype-phenotype correlation for GLI3 mutations. Any text you add should be original, not copied from other sources. Survival for a few years is possible, and in a small but increasing number of cases, surgery is effective.